Category Archives: Growth

The Emperor of all Maladies: Mukherjee’s look into Our Relationship with Cancer

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Siddartha Mukherjee’s first book, “The Emperor of All Maladies: A Biography of Cancer”, is the third of his I’ve read. My interest earlier, and still, remains in understanding the biology of the organism, so I read his books on genetics and the cell first, trying to improve my understanding of the complex actions and structures of life before attempting to understand a disease that ravages and destroys so many lives. His effort to write this book led to Mukherjee receiving the Pulitzer Prize. It is a gargantuan endeavor, artfully constructed. It contains several stories in an overlapping, although, natural style beginning with man’s earliest recorded conception of the disease(s). It becomes clearer and clearer as you read through it that cancer is more a ‘family’ of diseases, linked by their pattens and effects as they progress within the cell and from there, into the collective structures of our body, than it is a singular disease. But that gets way ahead.

Cancer is not a ‘new’. The ancient Greeks wrote of it and there are scattered records of it much earlier from other civilizations. Galen, wrote of it almost 2,000 years ago, attributing it to an imbalance in ‘black bile’, one of the four humors, which when out of balance, he claimed, lead to various diseases (This was the justification for the practice of ‘bleeding’ a patient that continued on into 18th and early 19th centuries, not that long ago). Such ‘humors’ were thought for centuries to be at the root of many diseases and infections across Europe until scientists, through the use of microscopes, began to understand that the cell was the basic building block of all life, and that there was a microbial world beneath and within the world readily observable to us. Galen’s views continued to hold sway until anatomists, through their careful dissections, realized that ‘black bile’ was a fabrication, an attempted explanation for something unseen at work within the body. Cancer then, along with our understanding of the body and disease, began its slow, lurching, advancement through the practice of science. What actually is cancer? Continue reading →

On Rediscovering the World We’ve Been Ignoring: An Introduction to the Life Sciences and Our Need For It

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Science is the study of life and the world around us, an exploration of the reality of the universe conducted from different ‘directions’ with the intent of understanding its endless aspects. Today, however, science in seeking to ‘peel back its layers, in attempting to clarify our place in it and improve the conditions within which we live along with our relationship with it, and each other, many have dismissed the effort and our effort to continue ‘doing’ science has become contentious. Knowing and its pursuit, has become a kind of ‘blasphemy’. Science has become politicized along with so much else. Many completely dismiss it as a wasteful effort, an attempt by elites to purposely complicate our lives with distractive and destructive nonsense, the value of expertise dismissed. For them life seems simple and obvious. Science, many claim, is an effort by ‘elites’ to obfuscate and to remove decision making ever further from the ‘people’…in doing this we are replacing curiosity and understanding with a willful ignorance, generalized fear and a ‘trust’ in those who simply, and loudly, claim to hold the answers, who demean all others and promise to return us to some ‘golden age’ fantasy of the past. They ‘reduce’ language, surrender clarity, replacing it with volume and repetition, shrink both what is acceptable for discussion and the lexicon with which we do so, rendering communications more open to confusion and misinterpretation, to manipulation. Language and speech, limited, regulated. Science can’t afford this. (Nor can any vital society.) Doubt and insecurity will overwhelm us, until we reclaim our right to knowledge. Reason, science and critical thinking, offer us a way out, a way to reclaim our agency, without destroying the world. Continue reading →

“Transformer: The Deep Chemistry of Life and Death”, a Review and Thoughts on this Life

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I begin this post in my usual way of attempting to incorporate the science presented in Lane’s book into my own understanding of life. That’s what I do through the first portions of this piece. Then I stray….discussing how I understand the process of homeostasis and what I see as the extension of this, relationship as integral to complexity itself, developing from necessary sensitivity, the ‘awareness’, necessary for internal communication,  signaling, responsiveness and, ultimately, the coordination of internal functioning and cognition, sentience and ,ultimately, intelligence. It is a process of accretion, with increasing complexity. The links between related ‘things’ are then not just physical, they are energetically connected. I’ll leave this now for later.

I’ve just finished reading evolutionary biochemist, Nick Lane’s latest book, “Transformer: The Deep Chemistry of Life and Death”.  It is not light reading. There are diagrams of chemical reactions, often with descriptions that urge the reader to not get overly hung up on them, the terms and steps. They are not simple processes. One transformation following another, necessarily, in precise order, until removed for other processes, other needs, the remainder augmented by what is required to continue on. Uninterrupted. Billions of times per second. He writes about the quantum hopping occurring in reactions instantaneously. Shared electrons. The flow of protons in the continuous ‘flux’ of life. The processes changing ‘directions’, spinning off secondary products, closing and reopening paths as the cell and organism works to maintain homeostasis, interpreting the seeming chaos of activity into the sustenance of life. It is a ‘story’ of constant metabolic change, patterned and ‘free’, the work of homeostasis that takes place within every organism. There is a lot here I write of not in the book, but which I’ve picked up in my other reading. And, again, I’ll remind you that as an intuiter, I combine ideas, works from disparate sciences and follow my own paths. This is another part of my journey to understanding this world.

His other books have been more accessible, for this reader anyway, but to move ahead in one’s understanding of life’s complexity, one has to have an understanding of the concepts and big ideas involved. Life isn’t magic. Its study can be simultaneously intimidating and fascinating as well as a wondrous process when look closely. I’ll be rereading this one to pick up more bits later. Continue reading →

On Biology, Ecology, Evolution: Health as a Product of an Engaged Life Aided by Science

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Biology, the ‘life sciences’, botany, evolution, cell biology, ecology, health and disease, plant communities, our relationship as humans with each other, geology and the life around us, are all topics that interest me. My most recent reading choices have focused on embryology and an organism’s capacity to maintain homeostasis, what is meant by ‘health’. Earlier I focused on the big question of ‘What is life?’ I’m an integrator, an intuitor, an assembler of conceptual puzzles. For me understanding is the goal and that usually involves understanding the ‘pieces’ of the puzzle and fitting them together into coherent wholes. That’s what I do when I select books and read. While my fiction choices are relatively wide and varied, when it comes to this question, I am far more focused, purposeful. I am not overly concerned with being correct in terms of conventional thought or even regarding that which is accepted as being scientifically correct. I’m looking for what makes ‘sense’. I ‘test’ what I read.

Science is conservative and rightly so. It works to define a foundation from which we may build on. Many, if not all scientific advances, came at the expense and pain of researchers who reach beyond the established to address the problems that accepted theory has revealed as the process advances. Egos and careers can get crushed. Arguably, every significant advance in science began as a controversial idea. Over time, with repeated experimentation, advances in technologies that enable scientists to address questions not previously possible, new insights and ways to ask the ‘question’, the new gains support, or alternatively, is revealed to be ‘wrong’. In this process other questions arise, that move us toward a more complete ‘truth’, a truth that enlightening and revealing, can never be the ultimate answer. What preceded it was not necessarily ‘wrong’, but more likely incomplete, unable to fully explain the world as our understanding of it itself changes. Science becomes a process of understanding at an ever finer scale. What once served, still does, but in a coarser grained way. Occasionally, it demands a radical rethink of our basic understanding of reality. Continue reading →

The Good Virus, A Review and Thoughts About the Necessity of an Informed Public

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Every book tells a story, even the driest academic tome…or rather, utilizes the form of a story. Humans communicate through story. It’s how we give some communicable ‘form’ to our thoughts which we can share. Without it everything is disconnected reportage of facts, personal impressions, emotions. Raw data. Zeros and ones. incomprehensible. To communicate through story requires that we share enough elements of the story, its language, form and ideas, with our ‘listener’, that they can understand what we are saying/writing. If it is too alien, communication does not happen. The listener/reader, hears the words, but the meaning eludes them. Meaning and experience are not shared. Without these, connection, communication, fails. The more esoteric the topic, the more important it is that both ‘parties’ share a common language, that  each is ‘educated’ to some degree, about the world the other is attempting to communicate. As science and technology become ever more specialized and schools and social institutions become more isolated from their larger communities, communication fails more often than not. Especially when the ‘other’ is viewed in a negative light, as untrustworthy. Communication then requires a leap of faith, because as our understanding of the world becomes deeper and more complex, we cannot all become expert in all things. There is just too much to learn. This is when effort, trust and faith, become essential. We must share a commonality, a trust in the other. As shared knowledge, and ‘ways of knowing’ decline, assumptions then dominate. Intentions then become suspect and the very possibility of community and communication evaporate. What we ‘see’, is what ‘we’ see, not what someone else does. Whether or not that is shared is the crux of the communication problem.  Continue reading →

The Seat of Awareness: On Plants and What We can Learn from Them

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“From the viewpoint of the evolutionary biologist it is reasonable to assume that the sensitive, embodied actions of plants and bacteria are part of the same continuum of perception and action that culminates in our most revered mental attributes. “Mind” may be the result of interacting cells. Mind and body, perceiving and living, are equally self-referring, self-reflexive processes already present in the earliest bacteria.”
—Lynn Margulis and Dorian Sagan, “What is Life?”, 1995

From what do sentience, awareness, consciousness and intelligence come from? Are these capacities a product of an organism’s complexity? At what point does it first appear? is it a property inherent to even the simplest organic chemicals? of peptide chains and amino acids, of atoms themselves?What of the organizing principle that seems to guide embryogenesis, the growth and form of every living individual of every species? Is it in action in the most ‘simple’ interactions between organic chemicals and the energy flowing through them, that favors one form over another and animates those same forms once they meet some critical minimal level of complexity?  Is this evolution towards complexity and ‘awareness’ an inevitability? A product of its component parts and the energies within it? [This is an idea that is separate from the notion of an inevitable ‘progress’ of life, always moving ‘forward’. Progress is a human notion, an assessment and a valuation of the change around us, not a ‘goal’ of natural selection and the animating ‘flux’ of energies within the universe.] Rudimentary awareness must exists at some necessary and basic level in the simplest single celled organisms…even in plants.

I look to that which is shared between all organisms and question the idea of the animal brain, and its neural system, as the basis for these things and its purported absence in plants, fungi, bacteria, viruses and archaea, as lacking in them. The brain itself and associated nervous system is a unique and complex structure present only in ‘higher’ animals. This bias in favor of the brain and neural systems, especially that of the human brain, as the seat of awareness and consciousness, ignores the requirements of any organism. We are biased in our insistence that these capacities must be located in a singular physical organ and no other. A singular occurrence in the universe. A huge conceit on our part, that this capacity exists in us alone, in and organ and tissues we could could physically evaluate, one which we ‘carry’ internally within us as we move freely about. The body, any body, is a vessel which contains life and is shaped by it. Life is both of the body and transcendent, existing beyond it. Life exists within the continuously unfolding moment. Life is not a ‘thing’ so one can hardly expect awareness, consciousness and intelligence to fit neatly into a limited organ, however we define it. The roots of this reach back into the study of evolution, ecology, cell biology, neurobiology, the metabolism and thermodynamics of life and the expanding field of quantum biology.

This latest thought piece has been inspired by three recent books I’ve read, Ed Yong’s, “An Immense World”, Paco Calvo’s, “Planta Sapiens” and Zoe Schlanger’s, “The Light Eaters”. I am not a scientist. I’m a student driven to make sense of this world. The connections and conclusions I make here are mine, although they may be suggested by the writings of others. Continue reading →

On Ornamental Trees and the Remaking/Unmaking of Place: Revising the City of Redmond’s Tree List, part 2

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How Much to Water?

Recommending trees from climates with significantly wetter growing seasons needs to stop if we are to continue growing our population. Landscapes as designed, and managed, are the single largest user of residential water. Recommending trees which ignore this problem is irresponsible. Lower water use residential landscapes are possible. Local codes and recommendations must, however, reflect this priority.

Additionally, how much to water is a bit of a mystery to all of us and especially so to non-gardeners. How much? How often? Our watering practices should be determined by the local precipitation and the tree’s needs. What is commonly done, however, is that we water for our lawns and that largely determines what our trees receive, unless we have separate drip systems. A tree’s root system doesn’t stay neatly between the lines. They quickly extend out well beyond the span of the tree’s leafy canopy. In many cases even 2-3 times as far, taking up water and nutrients. A roots of a tree, planted in a small bed, adjacent to an irrigated lawn area, will move out into the lawn. A tree isolated in a xeric bed with only a few drip emitters, will quickly demand more than such a meager system affords it and such a tree, if it requires summer moisture, will struggle while competing with its nearby  ground level growing neighbors. Again ‘neighbors’ should share compatible requirements so all can thrive on the same ‘diet’ and moisture regime. Continue reading →

The Gene: An Intimate History, a Review

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I finished reading Siddhartha Mukherjee’s book from 2016, “The Gene: An Intimate History”, a dense, engaging book, written in a prose style, conversational, thorough, accessible and personal, exceedingly rare qualities to find in a book covering such technical topic. Mukherjee, trained and worked as an oncologist, won the Pulitzer Prize for his earlier book on cancer, “The Emperor of all Maladies: A Biography of Cancer”. He is currently an associate professor of medicine at New York Presbyterian Hospital/Columbia University. Understood to be the ‘best’, or most complete and thorough history of genetics, our understanding of it and the ethical questions of its increasingly influential applications in medicine, society and evolution. Of such broad scope in the changing landscape of medicine and its science, it has expectedly, become subject to an array of criticisms. The practice of science is not perfect. Our understanding is forever evolving and as much as promoters might insist that theirs is solid and fixed, our knowledge will always be imperfect. We circle around a topic, defining it closer and closer, but never quite understanding it fully, questions leading us to more questions, our knowledge shaped by what we already ‘know’, and very occasionally propose entirely new ways of explaining, new theories, that dislodge previous established theory. Continue reading →

Determined: A Science of Life Without Free Will, a Review and Look Into its Consistency With the Sciences

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Long ago I took a couple philosophy classes at U of O; one on existentialism, in which we read several novels and discussed their themes; and another, an upper division, class on ethics, because I was curious…I dropped the ethics class after sitting around the table in seminar discussing particular authors’ thoughts, like Kierkegaard and Butler. Majors seemed to take pleasure in making fun of what I got from them in discussions. Hated this. I still have trouble reading philosophy. It seemed like a game to them in which they argued a position to show off their cleverness, their superiority, the ideas themselves of relatively little importance…while hiding their biases. It must have been so self-assuring for them to ‘know’ these author’s precise thoughts and bash those who don’t get it…or saw something different (like the newbie, me). To quote someone isn’t to understand, it is only miming, presumably in hope of getting a reward. I read for understanding. It’s not a competition. So, this book, “Determined: A Science of Life Without Free Will”, taking a science approach to evaluate a philosophical concept, was difficult to begin. The author, neuro-biologist Robert Sapolsky, argues that those philosophers and theologians who claim that people have free will to do whatever they desire or set their minds to, are wrong. This appealed to me immediately. Continue reading →

Song of the Cell: An Exploration of Medicine and the New Human, A Review

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The cell is the basic, irreducible, unit of life. Whether an organism is animal, plant, fungal or bacterial, the cell is its basic unit. While it can be broken down into its ‘parts’ for examination, none of those parts are capable of independent life, none are able to continue fulfilling their functions on their own. The cell and its ‘community of parts’ operate as a ‘social’ unit, as a whole. Each ‘part’ fulfills one or more roles in the ongoing life of the cell. This book is a review of cell biology, of the development of our, human, understanding of the life of the cell and its centrality to our understandings of what it is be alive, how it has and continues to transform our practice of medicine. The author, Siddhartha Mukherjee, is a doctor and researcher who has spent his professional life studying blood and its cancers, trying to understand and treat disease. Continue reading →