The cell is the basic, irreducible, unit of life. Whether an organism is animal, plant, fungal or bacterial, the cell is its basic unit. While it can be broken down into its ‘parts’ for examination, none of those parts are capable of independent life, none are able to continue fulfilling their functions on their own. The cell and its ‘community of parts’ operate as a ‘social’ unit, as a whole. Each ‘part’ fulfills one or more roles in the ongoing life of the cell. This book is a review of cell biology, of the development of our, human, understanding of the life of the cell and its centrality to our understandings of what it is be alive, how it has and continues to transform our practice of medicine. The author, Siddhartha Mukherjee, is a doctor and researcher who has spent his professional life studying blood and its cancers, trying to understand and treat disease. Continue reading
Category Archives: Disease
Spillover: Animal Infections and the Next Human Pandemic, David Quammen, WW Norton & Co.,2012; a Review
If you were perusing the library shelves and came across this book, the title “Spillover” may leave you a little uncertain in terms of its topic, without reading the subtitle and having some understanding of the processes described in the book, the emergence, evolution and ecology of ‘new’ diseases, human diseases. When we speak of them we understand them as conditions, assaults on our health and human bodies, which result in an array of symptoms, with wide ranging severity, ranging from mild and asymptomatic; to bothersome with knowable, short lived cycles; through chronic and debilitating; to those entailing a series of feverish cycles we simply must endure; to those often painful and fatal which wreck havoc on our systems and organs. Quammen, the author, is as always, an intelligent and thorough researcher able to interpret complex topics for the layman while staying true to the science and the people whose stories he tells as he weaves together the larger narrative. Continue reading
COVID-19, Pandemics and How They Will Change the World For the Better
I’m not a biological ‘fatalist’, but there are several reasons why epidemiologists were attempting to plan for a pandemic and why the Obama administration was empowering institutions, creating protocols and organizing resources that could be mobilized quickly, before the COViD-19 outbreak, not for this one specifically, but one of some kind. Viruses, bacteria, mycoplasma and other microbes fill the world at a microscopic level…they are everywhere, all of the time. Our own bodies contain far more of them than we do of our own some three trillion cells. Fortunately, most of them do not cause us disease, at least as long as we remain healthy. Many of them, in fact perform valuable functions in us, beneficial ones, without which our lives would be the poorer. Disease too is part of life’s ‘plan’. Its agents are dynamic. Today’s diseases are not those of the past. We evolved together. They mutate and sometimes ‘leap’ across species boundaries. A study of biology and disease reveals a function of disease or at least a consequence to the health and evolution of a species. It may sound heartless to put it this way, but disease is very much a part of living. With this new disease, COVID-19, as with others, it is selective, affecting those whose health is compromised in some way disproportionately, killing those most susceptible, the weak and those may include those surprising to us. As in most things concerning life, nothing is so simple as our concept of strong and weak. Disease is a part of the process of natural selection that has always been in effect in the world. Continue reading

On Amelanchier / Serviceberries: Their Susceptibility to Rust and Their Use in our Gardens
Sometimes we are drawn to plants by memories and sentiment, plants we have early associations with. They can regularly appear in our palette, our quiver of plants, that we might choose from. We all have our preferences, our biases. Sometimes the mismatch might only be aesthetic other times it can be a problem related to our site conditions. When we include these plants they may struggle, yet persist in the garden, maybe demonstrating to others their ‘ill-fit’. When a plant is a poor fit, its inclusion can become a glaring error to others that we are blinded to. Diseases can present such a problem, diseases that can be problematic in our area, or that our site is simply unfortunate enough to suffer from. ‘Rust’ diseases, Gymnosporangium spp., can be an issue here. In the case of Serviceberries, it can be disfiguring and debilitating. Several of these species attack Rose Family members, that include the Serviceberries, which seem particularly susceptible, though it doesn’t kill them. Diseased, stunted and suffering, unwilling to just die and put us both out of our misery, these plants continue. It is akin to being drawn to the wrong lover or life partner…it’s not going to work out and we simply can’t seem to help ourselves. Continue reading